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[Twenty-year follow-up study of antiglycolipid antibodies and electrophysiological findings in a 36-year-old patient with an axonal variant of Guillain-Barré syndrome].
- Source :
-
Rinsho shinkeigaku = Clinical neurology [Rinsho Shinkeigaku] 2018 Aug 31; Vol. 58 (8), pp. 509-512. Date of Electronic Publication: 2018 Jul 31. - Publication Year :
- 2018
-
Abstract
- We describe a twenty-year follow-up study of antiglycolipid antibodies and electrophysiological results in a 36-year-old man with Campylobacter jejuni-associated Guillain-Barré syndrome (GBS). The patient had a high titer of IgG antibodies to GM1 and GA1 20 years ago. Plasma exchange resulted in full recovery from a bedridden status to independent walking in three weeks, except for residual mild weakness of the bilateral extensor hallucis longus muscles and atrophy of the plantar muscles. Twenty years later, he is unable to run at full pace due to neurological sequelae, and IgG antibodies to GM1 and GA1 were still slightly positive. This case suggests that marked improvement in the acute phase does not necessarily guarantee a subsequent good quality of life (QOL). Optional treatment such as complement inhibitors in the acute phase may be required to achieve better QOL in subsets of patients with GBS.
- Subjects :
- Adult
Biomarkers blood
Campylobacter Infections
Campylobacter jejuni
Enteritis complications
Enteritis microbiology
Follow-Up Studies
Guillain-Barre Syndrome diagnosis
Guillain-Barre Syndrome physiopathology
Guillain-Barre Syndrome therapy
Humans
Male
Neural Conduction
Plasma Exchange
Prognosis
Time Factors
G(M1) Ganglioside immunology
Guillain-Barre Syndrome immunology
Immunoglobulin G blood
Quality of Life
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1882-0654
- Volume :
- 58
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Rinsho shinkeigaku = Clinical neurology
- Publication Type :
- Academic Journal
- Accession number :
- 30068808
- Full Text :
- https://doi.org/10.5692/clinicalneurol.cn-001148