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Albiglutide for the management of type 2 diabetes.
- Source :
-
Expert review of endocrinology & metabolism [Expert Rev Endocrinol Metab] 2018 Jan; Vol. 13 (1), pp. 1-8. Date of Electronic Publication: 2017 Dec 20. - Publication Year :
- 2018
-
Abstract
- Introduction: Albiglutide is a long acting GLP-1 receptor agonist (GLP-1 RA) administered by weekly injection and approved for use in type 2 diabetes. It has less gastrointestinal side effects than other GLP-1 RAs in current use but does not improve HbA1c or promote weight loss to the same extent as some competitor agents. Area covered: The current use of albiglutide is discussed. The review encompassed a search of PubMed and a thorough analysis of the European Union and US Food and Drug Administration approval documents. Expert opinion: Unlike competitor agents, the gastrointestinal side effects of albiglutide are not much greater than placebo. It has been studied and appears safe at all stages of renal failure. There exists concern about an imbalance of pancreatitis cases in the approval program as well as injection site reactions which led to discontinuance of therapy in up to 2% of participants. A large long-term study is now underway to determine if albiglutide, with its relatively favorable GI tolerance, has a place in the treatment of patients with increased risk of cardiovascular events. At present, albiglutide is a safe agent to introduce GLP-1 RA treatment into the regimen for type 2 diabetes patients and may be the GLP-1 agent of choice in patients with renal insufficiency.
- Subjects :
- Glucagon-Like Peptide 1 adverse effects
Glucagon-Like Peptide 1 pharmacology
Glucagon-Like Peptide 1 therapeutic use
Humans
Hypoglycemic Agents adverse effects
Hypoglycemic Agents pharmacology
Diabetes Mellitus, Type 2 drug therapy
Glucagon-Like Peptide 1 analogs & derivatives
Glucagon-Like Peptide-1 Receptor agonists
Hypoglycemic Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8417
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Expert review of endocrinology & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 30063441
- Full Text :
- https://doi.org/10.1080/17446651.2018.1419061