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Biodegradable Poly(amino acid)-Gold-Magnetic Complex with Efficient Endocytosis for Multimodal Imaging-Guided Chemo-photothermal Therapy.
- Source :
-
ACS nano [ACS Nano] 2018 Sep 25; Vol. 12 (9), pp. 9022-9032. Date of Electronic Publication: 2018 Aug 20. - Publication Year :
- 2018
-
Abstract
- Gold complexes can serve as efficient photothermal converters for cancer therapy, but their non-biodegradability hinders clinical bioapplications. Although enormous effort has been devoted, the conventionally adopted synthetic methods of biodegradation are characterized by high cost and complicated procedures, which delay the process of further clinical translation of gold complexes. Here, we report a multifunctional poly(amino acid)-gold-magnetic complex with self-degradation properties for synergistic chemo-photothermal therapy via simple and green chemistry methods. Nanoparticles of ∼3 nm in the biodegradation product were observed in simulated body fluid in 4 days. The biodegradability mainly benefits from the weakened internal electrostatic interaction of the poly(amino acid) by the ions in simulated body fluid. It is demonstrated that the poly(amino acid)-gold-magnetic complex has great cellular endocytosis by taking advantage of the guanidine group in arginine and possesses multimodal imaging and efficient tumor ablation (94%). This study reports a possibility for gold-magnetic complexes composed of poly(amino acid) to serve as a biodegradable nanotherapeutic for clinical applications.
- Subjects :
- Animals
Antibiotics, Antineoplastic chemistry
Biocompatible Materials metabolism
Cell Line, Tumor
Doxorubicin chemistry
Endocytosis drug effects
Female
Gold metabolism
Mammary Neoplasms, Animal diagnostic imaging
Mammary Neoplasms, Animal metabolism
Mice
Mice, Inbred BALB C
Polyglutamic Acid metabolism
Static Electricity
Antibiotics, Antineoplastic pharmacology
Biocompatible Materials chemistry
Doxorubicin pharmacology
Gold chemistry
Magnetite Nanoparticles chemistry
Mammary Neoplasms, Animal therapy
Phototherapy
Polyglutamic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 12
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 30059614
- Full Text :
- https://doi.org/10.1021/acsnano.8b02750