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Tetrahedral DNAzymes for enhanced intracellular gene-silencing activity.

Authors :
Thai HBD
Levi-Acobas F
Yum SY
Jang G
Hollenstein M
Ahn DR
Source :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 Aug 21; Vol. 54 (68), pp. 9410-9413.
Publication Year :
2018

Abstract

We prepared tetrahedral DNAzymes (TDzs) to overcome potential limitations such as insufficient serum stability and poor cellular uptake of single-stranded DNAzymes (ssDzs). TDzs showed enhanced serum stability and higher cellular uptake efficiency compared to those of ssDzs, providing significantly improved intracellular gene-silencing activity to down-regulate the target mRNA level.

Subjects

Subjects :
Animals
Cattle
DNA, Catalytic chemistry
DNA, Single-Stranded chemistry
DNA, Single-Stranded genetics
Down-Regulation
Fibroblasts metabolism
Kinetics
Mice
NIH 3T3 Cells
Nanostructures chemistry
Nucleic Acid Hybridization
RNA, Messenger genetics
RNA, Messenger metabolism
DNA, Catalytic genetics
Gene Silencing

Details

Language :
English
ISSN :
1364-548X
Volume :
54
Issue :
68
Database :
MEDLINE
Journal :
Chemical communications (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
30059088
Full Text :
https://doi.org/10.1039/c8cc05721d
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