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Blockade of synaptic activity in the neostriatum and activation of striatal efferent pathways produce opposite effects on panic attack-like defensive behaviours evoked by GABAergic disinhibition in the deep layers of the superior colliculus.
- Source :
-
Physiology & behavior [Physiol Behav] 2018 Nov 01; Vol. 196, pp. 104-111. Date of Electronic Publication: 2018 Jul 25. - Publication Year :
- 2018
-
Abstract
- The dorsal periaqueductal grey matter (dPAG) and the deep layers of the superior colliculus (dlSC) have been implicated in the organisation of innate fear-related defensive behaviours. Furthermore, GABAergic neurons from the substantia nigra pars reticulata (SNpr) connected to the dlSC and dPAG receive convergent disinhibitory inputs from the caudate-putamen (CPu), comprising the neostriatum, and modulate defence responses elicited by midbrain tectum stimulation. The purpose of this work was to study the effect of either excitatory cortico-neostriatal input blockade or neostriato-nigral GABAergic disinhibitory output activation on the responsivity of GABAergic nigro-collicular tonic inhibitory pathways during the elicitation of panic attack-like defensive responses produced by bicuculline administration into the dlSC. Thus, we investigated the effects of microinjection of either the synaptic activity blocker cobalt chloride (CoCl <subscript>2</subscript> ) or the NMDA receptor agonist N-methyl-D-aspartic acid in the CPu on the elaboration of the defensive behaviour elicited by the selective blockade of GABA <subscript>A</subscript> receptors in the dlSC. Our findings showed that pretreatment of the neostriatum with CoCl <subscript>2</subscript> caused clear anxiolytic and panicolytic-like effects, reducing the incidence and duration of alertness and diminishing defensive immobility and explosive escape responses. On the other hand, pretreatment of the neostriatum with NMDA (40 nmol) caused a pro-aversive effect, enhancing running and jumping responses elicited by GABAergic disinhibition in the dlSC. We conclude from the data that the neostriato-nigral disinhibitory and nigro-collicular inhibitory GABAergic pathways modulate innate fear and panic attack-like responses organised by dlSC neurons.<br /> (Copyright © 2018. Published by Elsevier Inc.)
- Subjects :
- Animals
Behavior, Animal drug effects
Cobalt pharmacology
Corpus Striatum drug effects
Efferent Pathways drug effects
Efferent Pathways physiopathology
Male
Motor Activity drug effects
Motor Activity physiology
N-Methylaspartate metabolism
N-Methylaspartate pharmacology
Neural Inhibition drug effects
Neural Inhibition physiology
Neurotransmitter Agents pharmacology
Rats, Wistar
Receptors, GABA-A metabolism
Superior Colliculi drug effects
Synaptic Transmission drug effects
Behavior, Animal physiology
Corpus Striatum physiopathology
Panic Disorder physiopathology
Superior Colliculi physiopathology
Synaptic Transmission physiology
gamma-Aminobutyric Acid metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-507X
- Volume :
- 196
- Database :
- MEDLINE
- Journal :
- Physiology & behavior
- Publication Type :
- Academic Journal
- Accession number :
- 30055218
- Full Text :
- https://doi.org/10.1016/j.physbeh.2018.07.021