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Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing.

Authors :
Burton DGA
Faragher RGA
Source :
Biogerontology [Biogerontology] 2018 Dec; Vol. 19 (6), pp. 447-459. Date of Electronic Publication: 2018 Jul 27.
Publication Year :
2018

Abstract

Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. This can consequently manifest as age-related biological impairments and secondary diseases. Cell senescence in cell types linked with obesity and diabetes, namely adipocytes and pancreatic beta cells will be explored, followed by a discussion on the role of obesity and diabetes in accelerating ageing through induction of premature cell senescence mediated by high glucose levels and oxidised low-density lipoproteins. Particular emphasis will be placed on accelerated cell senescence in endothelial progenitor cells, endothelial cells and vascular smooth muscle cells with relation to cardiovascular disease and proximal tubular cells with relation to kidney disease. A summary of the potential strategies for therapeutically targeting senescent cells for improving health is also presented.

Details

Language :
English
ISSN :
1573-6768
Volume :
19
Issue :
6
Database :
MEDLINE
Journal :
Biogerontology
Publication Type :
Academic Journal
Accession number :
30054761
Full Text :
https://doi.org/10.1007/s10522-018-9763-7