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Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing.
- Source :
-
Biogerontology [Biogerontology] 2018 Dec; Vol. 19 (6), pp. 447-459. Date of Electronic Publication: 2018 Jul 27. - Publication Year :
- 2018
-
Abstract
- Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. This can consequently manifest as age-related biological impairments and secondary diseases. Cell senescence in cell types linked with obesity and diabetes, namely adipocytes and pancreatic beta cells will be explored, followed by a discussion on the role of obesity and diabetes in accelerating ageing through induction of premature cell senescence mediated by high glucose levels and oxidised low-density lipoproteins. Particular emphasis will be placed on accelerated cell senescence in endothelial progenitor cells, endothelial cells and vascular smooth muscle cells with relation to cardiovascular disease and proximal tubular cells with relation to kidney disease. A summary of the potential strategies for therapeutically targeting senescent cells for improving health is also presented.
- Subjects :
- Animals
Cardiovascular Diseases etiology
Disease Models, Animal
Glucose metabolism
Humans
Kidney Diseases etiology
Lipoproteins, LDL metabolism
Mice
Molecular Targeted Therapy
Neoplasms etiology
Adipocytes pathology
Aging
Cellular Senescence
Diabetes Mellitus, Type 2 pathology
Insulin-Secreting Cells pathology
Obesity pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6768
- Volume :
- 19
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biogerontology
- Publication Type :
- Academic Journal
- Accession number :
- 30054761
- Full Text :
- https://doi.org/10.1007/s10522-018-9763-7