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Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei.
- Source :
-
Annals of coloproctology [Ann Coloproctol] 2018 Aug; Vol. 34 (4), pp. 222-225. Date of Electronic Publication: 2018 Jul 26. - Publication Year :
- 2018
-
Abstract
- Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days. The tumor had a high proliferation rate (mitotic count > 50/10 HPFs and 90% of the Ki-67 index) and lymph-node metastases had occurred. On immunohistochemistry, the tumor cells expressed CD56 and synaptophysin. Large-cell NEC was confirmed. Systemic chemotherapy with cisplatin/etoposide was done. The patient is still alive after 3 years with no evidence of recurrence.
Details
- Language :
- English
- ISSN :
- 2287-9714
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of coloproctology
- Publication Type :
- Academic Journal
- Accession number :
- 30048995
- Full Text :
- https://doi.org/10.3393/ac.2018.02.27