Two new secoiridoid glucosides and a new lignan from the roots of Ilex pubescens.

Two new secoiridoid glucosides, ilexpublignoside (1), pubzenoside (2), and a new lignan, ilexlignan B (3), along with seven known compounds (4-10) were isolated from the roots of Ilex pubescens for the first time. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including IR, UV, HR-ESI-MS, CD, NMR experiments, as well as comparison with the reported data.