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Tissue distribution and elimination features of florfenicol in hybrid sturgeon cultured in cool water.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2018 Dec; Vol. 41 (6), pp. 894-901. Date of Electronic Publication: 2018 Jul 25. - Publication Year :
- 2018
-
Abstract
- In order to understand pharmacokinetics in vivo and tissue residues of florfenicol in Hybrid sturgeon cultured in cold water, changes in concentration of florfenicol in plasma, muscle, liver and kidney of sturgeon after administration were measured by high performance liquid chromatography mass spectrometry. The results show that after 15.0 mg/kg dose administration, the concentration change in plasma and liver, kidney and muscle of sturgeon are suitable for the one compartment open model. Florfenicol pharmacokinetic parameters in plasma, liver, kidney and sturgeon muscle showed that the peak concentration (C <subscript>max</subscript> ) were 549.7, 551.8, 958.2 and 405.4 μg/kg, respectively. The peak time (T <subscript>max</subscript> ) was 17.5, 14.2, 14.0 and 20.8 hr, respectively. The elimination half-life (T <subscript>1/2</subscript> ) was 75.1, 99.8, 68.8 and 75.5 hr, respectively. Area under the curve were 70,048.9, 63,850.6, 109,579.9 and 53,437.3 μg/kg hr, respectively. Mean residence time was 100.6, 96.4, 96.5 and 104.6 hr, respectively. The absorption speed and elimination of florfenicol in cold water cultured sturgeon is slow, and the peak concentration is low, but the florfenicol was widely distributed in the body of sturgeon. The results provide a theoretical basis for formulation of medication and withdrawal period of florfenicol used in sturgeon cultured in cold water.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Anti-Bacterial Agents blood
Area Under Curve
Cold Temperature
Fishes blood
Fishes genetics
Half-Life
Hybridization, Genetic
Kidney metabolism
Liver chemistry
Liver metabolism
Muscle, Skeletal metabolism
Reproducibility of Results
Thiamphenicol blood
Thiamphenicol pharmacokinetics
Anti-Bacterial Agents pharmacokinetics
Fishes metabolism
Thiamphenicol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2885
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 30043988
- Full Text :
- https://doi.org/10.1111/jvp.12689