Back to Search
Start Over
Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study.
- Source :
-
Ultrastructural pathology [Ultrastruct Pathol] 2018 Jul-Aug; Vol. 42 (4), pp. 369-375. Date of Electronic Publication: 2018 Jul 24. - Publication Year :
- 2018
-
Abstract
- This is a case report of a 46-year-old white male who presented with dyspnea. Thoracic and abdominal examinations showed a heterogeneously enhancing mass in the right kidney, multiple pulmonary nodules, and left pleural thickening with large pleural effusion. Pleura biopsy revealed a malignant neoplasm composed of cells with predominantly clear cytoplasm. Considering the large mass in the right kidney, clear cell renal cell carcinoma (RCC) was the main differential diagnosis. The diagnosis in this case was not definitive by histology alone since clear cell RCC markers such as RCC and AE1/AE3 were negative, and CD10 was only focally positive. Transcription factor E3 (TFE3) immunohistochemistry was positive, while the XP11.2 translocation testing was negative. Electron microscopy demonstrated that the tumor cells had abundant cytoplasmic glycogen and lipid, focal long microvilli lining rare lumina, and adjacent interdigitating cell membranes joining the neoplastic cells, indicating a diagnosis of renal clear cell carcinoma. In addition, numerous crystalline-like dense granules were identified in the cytoplasm of the neoplastic cells, which are reminiscent of those typically seen in alveolar soft part sarcoma and rarely described in XP11.2 translocation RCC. Overall, this renal tumor likely represents a variant of XP11.2 translocation RCC, overexpressing TFE3 with dense granules.
- Subjects :
- Adult
Carcinoma, Renal Cell diagnosis
Humans
Immunohistochemistry methods
In Situ Hybridization, Fluorescence methods
Kidney Neoplasms diagnosis
Male
Oncogene Proteins, Fusion genetics
Sarcoma, Alveolar Soft Part diagnosis
Carcinoma, Renal Cell pathology
Kidney pathology
Kidney Neoplasms pathology
Oncogene Proteins, Fusion ultrastructure
Sarcoma, Alveolar Soft Part pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-0758
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Ultrastructural pathology
- Publication Type :
- Academic Journal
- Accession number :
- 30040522
- Full Text :
- https://doi.org/10.1080/01913123.2018.1499686