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DWI-MRI vs CT in gastric MALT lymphoma-preliminary results in 19 patients.

Authors :: Berzaczy D
Staudenherz A
Raderer M
Weber M
Mayerhoefer ME
Source :: The British journal of radiology [Br J Radiol] 2019 Jan; Vol. 92 (1093), pp. 20180263. Date of Electronic Publication: 2018 Jul 24.
Publication Year :: 2019
Abstract: Objective: To assess the diagnostic performance of [F <superscript>18</superscript> ] fluoro-2-desoxy-D-glucose positron emission tomography/CT [( <superscript>18</superscript> F) FDG-PET/CT] compared to diffusion-weighted imaging (DWI)-MRI of lesion detection in patients with non-FDG avid gastric mucosa-associated lymphoid tissue (MALT) lymphoma.<br />Methods: 19 patients with histologically proven gastric MALT lymphoma were included in this prospective Institutional Review Board-approved study. Patients underwent [ <superscript>18</superscript> F]-FDG-PET/CT and consecutive MRI/DWI. Images were evaluated for the presence of gastric lesions in two anatomically defined groups (region 1: cardia, body, fundus; region 2: antrum, pyloric region) by two senior board-certified radiologists, in an observer-blinded manner. Overall accuracy relative to the reference standard (histology obtained by biopsy) was calculated for each reader and a consensus rating.<br />Results: We found a statistically significant higher accuracy of lesion detection for lesions in region 1 ( p = 0.030) and 2 ( p = 0.070) for DWI-MRI (100%/78.9%) than for CT (68.4%/42.1%).<br />Conclusion: DWI-MRI seems to be superior accurate to CT for lesion detection in non-FDG avid gastric MALT lymphoma.<br />Advances in knowledge: DWI-MRI seems to be an alternative reliable imaging method for locoregional disease evaluation of non-FDG avid gastric MALT lymphoma.