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Crossmatching Maternal and Fetal Blood in Sheep.
- Source :
-
Comparative medicine [Comp Med] 2018 Aug 01; Vol. 68 (4), pp. 294-297. Date of Electronic Publication: 2018 Jul 23. - Publication Year :
- 2018
-
Abstract
- We investigated the incidence of ex vivo incompatibility between ovine maternal RBC and fetal plasma. Time-mated singleton pregnant ewes (n = 8) underwent cesarean delivery of the fetus; at the time of delivery, paired maternal and fetal blood samples were collected and subsequently separated for storage as packed RBC and fresh frozen plasma. Gel column crossmatching was performed 3 to 4 wk later. All fetus-dam crossmatches were considered major crossmatches, combining fetal (recipient) plasma with dam (donor) RBC. The plasma of 8 fetuses was cross-matched with RBC from 5 dams; all autologous controls were negative, and all but one crossmatch (1 of 40, 2.5%) were considered compatible. In addition, the plasma of 3 dams was crossmatched with RBC from 5 dams; all autologous controls were negative; however, significant incompatibility was noted. In total, 4 of 13 (30.8%) dam-dam crossmatches were considered incompatible. The results of this initial study suggest that when a single animal receives multiple blood-product transfusions, the risk of an immunologic transfusion reaction can be reduced by ensuring that the blood products are obtained from a single donor, performing a crossmatch prior to transfusion, and the use of synthetic products to increase the oxygen carrying capacity of fetal blood.
Details
- Language :
- English
- ISSN :
- 2769-819X
- Volume :
- 68
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Comparative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 30037360
- Full Text :
- https://doi.org/10.30802/AALAS-CM-17-000126