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Platelet-Rich Plasma Fat Graft versus Cartilage Perichondrium for Repair of Medium-Size Tympanic Membrane Perforations.
- Source :
-
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2019 Jan; Vol. 160 (1), pp. 116-121. Date of Electronic Publication: 2018 Jul 24. - Publication Year :
- 2019
-
Abstract
- Objectives: To compare clinical and audiologic outcomes among patients who underwent myringoplasty with fat graft enriched with platelet-rich plasma and cartilage perichondrium graft.<br />Study Design: Prospective randomized controlled study.<br />Setting: Department of Otolaryngology-Head and Neck Surgery, Tanta University, Egypt.<br />Subjects and Methods: The study comprised 50 patients who had tympanic membrane perforation of medium size (25%-50% of its surface area) without evidence of active otitis media or ossicular abnormalities and who had surgery between December 2016 and December 2017. Patients randomly underwent myringoplasty with fat graft enriched with platelet-rich plasma (group 1) or cartilage perichondrium graft (group 2).<br />Results: Twenty-five patients were included in each group. Rates of successful closure at 3-month follow-up were 88% (group 1) and 92% (group 2). The mean overall improvement in pure tone average was 18.08 dB (95% CI, 16.9-19.25) for group 1 and 18.24 dB (95% CI, 16.94-19.53) for group 2.<br />Conclusion: Fat graft enriched with platelet-rich plasma can be recommended as an alternative choice for first-line treatment of medium-size central perforations of the tympanic membrane, with healing and hearing results comparable to those of conventional cartilage perichondrium myringoplasty.
- Subjects :
- Adult
Egypt
Female
Follow-Up Studies
Graft Rejection
Graft Survival
Hearing Tests
Humans
Male
Middle Aged
Myringoplasty adverse effects
Prospective Studies
Recovery of Function
Risk Assessment
Statistics, Nonparametric
Treatment Outcome
Tympanic Membrane Perforation diagnosis
Young Adult
Adipose Tissue transplantation
Cartilage transplantation
Myringoplasty methods
Platelet-Rich Plasma
Tympanic Membrane Perforation surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6817
- Volume :
- 160
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 30037309
- Full Text :
- https://doi.org/10.1177/0194599818789146