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Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.
- Source :
-
PloS one [PLoS One] 2018 Jul 23; Vol. 13 (7), pp. e0201065. Date of Electronic Publication: 2018 Jul 23 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Introduction: Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.<br />Methods: The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped.<br />Results: The mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 μg/l vs. 856.6±13.05 μg/l, p<0.01). When compared in quartiles a significant association of higher zinc concentration with the incidence of prostate cancer was observed. The highest OR (OR = 4.41, 95%CI 2.07-9.37, p<0.01) was observed in 3rd quartile (>853.0-973.9 μg/l). Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19-4.82, p = 0.015).<br />Conclusion: Our results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.<br />Competing Interests: JL is CEO of Read-Gene S.A. The authors WM, MM are employees of Read-Gene S.A. KB, PB, GS, KD, TG, KP, CC, TH, JG, TD, RJS, AJ declare that they have no competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
- Subjects :
- Case-Control Studies
Genetic Predisposition to Disease
Humans
Incidence
Male
Matrix Metalloproteinase 1 genetics
Matrix Metalloproteinase 13 genetics
Matrix Metalloproteinase 2 genetics
Metallothionein genetics
Poland epidemiology
Prostatic Neoplasms epidemiology
Retrospective Studies
White People genetics
Matrix Metalloproteinase 7 genetics
Polymorphism, Single Nucleotide
Prostatic Neoplasms blood
Prostatic Neoplasms genetics
Zinc blood
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30036379
- Full Text :
- https://doi.org/10.1371/journal.pone.0201065