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Next-generation sequencing and prenatal 'omics: advanced diagnostics and new insights into human development.
- Source :
-
Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2018 Aug; Vol. 20 (8), pp. 791-799. Date of Electronic Publication: 2018 Jul 22. - Publication Year :
- 2018
-
Abstract
- Prenatal genetics has evolved over the last decade to include application of new 'omics technologies to improve perinatal care. The clinical utility of these technologies when applied to direct fetal specimens from amniocentesis or chorionic villus sampling is being explored. In this review, we provide an overview of use of prenatal exome sequencing and role in evaluation of the structurally abnormal fetus, potential applications of genome sequencing, and finally, use of transcriptomics to assess placental and fetal well-being.
Details
- Language :
- English
- ISSN :
- 1530-0366
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Genetics in medicine : official journal of the American College of Medical Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 30032162
- Full Text :
- https://doi.org/10.1038/s41436-018-0087-4