Back to Search
Start Over
Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2018 Nov 01; Vol. 171, pp. 115-122. Date of Electronic Publication: 2018 Jul 11. - Publication Year :
- 2018
-
Abstract
- The aim of the work was to extract, characterize, and formulate Thymus capitatus (Tymbra capitata) essential oil in phospholipid vesicles: liposomes, glycerosomes and Penetration Enhancer-containing Vesicles (PEVs). The steam-distilled essential oil was mainly composed of carvacrol. The oil was mixed with lecithin and water to produce liposomes, or different ratios of water/glycerol or water/propylene glycol (PG) to produce glycerosomes and PG-PEVs, respectively. Cryo-TEM showed the formation of unilamellar, spherical vesicles, and light scattering disclosed that their size increased in the presence of glycerol or PG, which improved long-term stability. The formulations were highly biocompatible, and capable of counteracting oxidative stress and favouring wound repair in keratinocytes, thanks to enhanced uptake. The antibacterial activity of the oil was demonstrated against cariogenic Streptococcus mutans, Lactobacillus acidophilus, and commensal Streptococcus sanguinis. The combination of antioxidant and antibacterial activities of Thymus essential oil formulations may be useful for the treatment of oral cavity diseases.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Antioxidants chemistry
Antioxidants isolation & purification
Cell Survival drug effects
Humans
Keratinocytes drug effects
Lactobacillus drug effects
Microbial Sensitivity Tests
Oils, Volatile chemistry
Oils, Volatile isolation & purification
Particle Size
Streptococcus drug effects
Surface Properties
Anti-Bacterial Agents pharmacology
Antioxidants pharmacology
Mouth Diseases drug therapy
Mouth Diseases microbiology
Oils, Volatile pharmacology
Phospholipids chemistry
Thymus Plant chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 171
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 30025373
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2018.07.021