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Ethanol sclerotherapy or polidocanol sclerotherapy for symptomatic hepatic cysts.
- Source :
-
United European gastroenterology journal [United European Gastroenterol J] 2018 Jul; Vol. 6 (6), pp. 919-925. Date of Electronic Publication: 2018 Mar 08. - Publication Year :
- 2018
-
Abstract
- Background: Over the past decades, multiple approaches to aspiration sclerotherapy of large symptomatic hepatic cysts have been investigated. However, comparative data are scarce.<br />Objective: The objective of this article is to compare cyst reduction, symptomatic relief, and adverse events between ethanol sclerotherapy and polidocanol sclerotherapy.<br />Methods: This retrospective study included adults having a symptomatic hepatic cyst treated at a European tertiary referral center with ethanol sclerotherapy (Center 1) or polidocanol-sclerotherapy (Center 2). We compared cyst diameter reduction (%) and symptom improvement (yes/no) within 12 months' post-treatment between centers using multivariate regression analyses adjusted for confounding factors. Finally, we compared adverse events using Fisher's exact test.<br />Results: We included 71 patients from Center 1 and 66 patients from Center 2 (median age 57 years; 126/137 (92%) female). Cyst reduction was comparable between Centers 1 and 2: 37.5% (IQR 15.7-61.0%) versus 44.2% (IQR 24.6-60.5%), respectively ( p = 0.35). Correspondingly, symptomatic relief was comparable: 30/53 (56.6%) versus 43/66 (65.2%), respectively ( p = 0.88). Center 1 reported significantly more (11 versus 3; p = 0.047) adverse events than Center 2.<br />Conclusion: We found comparable cyst reduction and symptomatic relief rates between ethanol- and polidocanol sclerotherapy, while adverse events occurred more often in the ethanol group. Prospective studies focused on clinical response are needed to further explore differences between approaches.
Details
- Language :
- English
- ISSN :
- 2050-6406
- Volume :
- 6
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- United European gastroenterology journal
- Publication Type :
- Academic Journal
- Accession number :
- 30023070
- Full Text :
- https://doi.org/10.1177/2050640618764940