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Central nervous system lymphoma in 18 dogs (2001 to 2015).

Authors :: LaRue MK
Taylor AR
Back AR
Lindley SE
Boudreaux BL
Almond GT
Shores A
Brawner WR
Smith AN
Source :: The Journal of small animal practice [J Small Anim Pract] 2018 Sep; Vol. 59 (9), pp. 547-552. Date of Electronic Publication: 2018 Jul 19.
Publication Year :: 2018
Abstract: Objectives: To investigate the outcome of dogs with central nervous system lymphoma.<br />Materials and Methods: A multi-center, retrospective, observational study was conducted by reviewing medical records of 18 cases of central nervous system lymphoma from seven institutions.<br />Results: Diagnosis of lymphoma was made through cerebrospinal fluid analysis, histopathology, flow cytometry of the cerebrospinal fluid, and cytology of cerebrospinal fluid, lymph node or spleen with correlated imaging. A total of 15 of 18 dogs received specific treatment other than prednisone. Three dogs underwent chemotherapy and radiation therapy after surgical decompression, five dogs underwent chemotherapy, two dogs underwent radiation therapy after surgical decompression, three dogs underwent chemotherapy after surgical decompression and two dogs underwent radiation therapy and chemotherapy. Only one dog received prednisone, and two dogs did not receive any treatment. Overall, the median survival time was 171 days (range 1 to 1942 days).<br />Clinical Significance: Dogs receiving any type of treatment for central nervous system lymphoma lived longer than cases described in previous historical reports. Further studies are needed to elucidate the importance of specific treatment modalities.<br /> (© 2018 British Small Animal Veterinary Association.)