Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags.

Authors :: Breukels O
van der Gronde T
Simons-Sanders K
Crul M
Source :: International journal of pharmaceutical compounding [Int J Pharm Compd] 2018 Jul-Aug; Vol. 22 (4), pp. 345-349.
Publication Year :: 2018
Abstract: Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.<br /> (Copyright© by International Journal of Pharmaceutical Compounding, Inc.)