Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells.

Authors :: Verheyen J
Thielen A
Lübke N
Dirks M
Widera M
Dittmer U
Kordelas L
Däumer M
de Jong DCM
Wensing AMJ
Kaiser R
Nijhuis M
Esser S
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2019 Feb 01; Vol. 68 (4), pp. 684-687.
Publication Year :: 2019
Abstract: Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.

Subjects :: HIV physiology
Humans
Receptors, CCR5 deficiency
Receptors, CXCR4 physiology
Treatment Outcome
HIV isolation & purification
HIV Infections therapy
Stem Cell Transplantation methods
Transplantation, Homologous methods
Viral Load
Viral Tropism

Language :: English
ISSN :: 1537-6591
Volume :: 68
Issue :: 4
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 30020413
Full Text :: https://doi.org/10.1093/cid/ciy565

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