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Dual-energy CT-based iodine quantification to differentiate abdominal malignant lymphoma from lymph node metastasis.
Dual-energy CT-based iodine quantification to differentiate abdominal malignant lymphoma from lymph node metastasis.
- Source :
-
European journal of radiology [Eur J Radiol] 2018 Aug; Vol. 105, pp. 255-260. Date of Electronic Publication: 2018 Jun 22. - Publication Year :
- 2018
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Abstract
- Purpose: To investigate the value of dual-energy computed tomography (DECT)-derived iodine and fat quantification in differentiating malignant abdominal lymphoma from lymph node metastasis.<br />Materials and Methods: In this retrospective study, 59 patients (39 men; mean age, 62.7 years) with histopathologically-confirmed diagnosis of either malignant lymphoma or lymph node metastasis were included. For each lesion, contrast-enhanced attenuation, as well as DECT-derived iodine density and fat fraction measurements were recorded. Mean attenuation and material density values were compared between malignant lymphomas and lymph node metastases. The receiver operating characteristic (ROC) curve analysis was adopted to estimate the optimal threshold for discriminating between both entities. A control group (n = 60) was analyzed for comparison of attenuation and material density values of normal abdominal lymph nodes.<br />Results: Assessment of DECT-derived iodine density and fat fraction values revealed significant differences between lymph node metastases (1.7 ± 0.4 mg/ml and 15.5 ± 7.3%) and malignant lymphomas (2.5 ± 0.5 mg/ml and 26.7 ± 12.2%) as well as normal lymph nodes (2.4 ± 0.8 mg/ml and 24.1 ± 10.8%) (P ≤ 0.013). An iodine concentration of 2.0 mg/ml represented the optimal threshold to discriminate between lymphoma and lymph node metastasis (sensitivity, 87%; specificity, 89%). Moreover, a significant correlation was found between iodine concentration and fat fraction for both lymphomas and lymph node metastases (P = 0.001).<br />Conclusion: DECT enables characterization of abdominal masses as derived iodine and fat fraction values differ significantly between malignant abdominal lymphomas and lymph node metastases.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Abdomen pathology
Adult
Aged
Diagnosis, Differential
Female
Humans
Iodine
Lymph Nodes diagnostic imaging
Lymphatic Metastasis pathology
Lymphoma pathology
Male
Middle Aged
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Abdomen diagnostic imaging
Lymph Nodes pathology
Lymphatic Metastasis diagnostic imaging
Lymphoma diagnostic imaging
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 105
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 30017291
- Full Text :
- https://doi.org/10.1016/j.ejrad.2018.06.017