Back to Search
Start Over
Developing a radiosensitivity gene signature for Caucasian patients with breast cancer.
- Source :
-
Oncology reports [Oncol Rep] 2018 Sep; Vol. 40 (3), pp. 1695-1705. Date of Electronic Publication: 2018 Jul 12. - Publication Year :
- 2018
-
Abstract
- Adjuvant radiotherapy is an important clinical treatment option for patients with breast cancer. However, for Caucasian patients, the clinical benefit of adjuvant radiotherapy can differ from African‑American patients with respect to the overall survival. The goal of the current study was to develop a gene signature and to pre‑identify patients likely to benefit from radiotherapy. Using publicly available breast cancer data from The Cancer Genome Atlas, a new cross‑validation procedure was proposed for developing a gene signature and predicting radiosensitive patients. The results demonstrated that the predicted radiosensitive patients who received radiotherapy exhibited a significantly better survival, while the effect of radiotherapy was not significant for predicted non‑radiosensitive patients. Further hierarchical cluster analysis revealed that the predicted sensitivity for each patient corresponded closely to the results of the cluster analysis. Collectively, the findings of the current study demonstrated that a radiosensitive molecular signature can be used to identify radiosensitive Caucasian patients with breast cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast Neoplasms pathology
Breast Neoplasms radiotherapy
Carcinoma, Ductal, Breast pathology
Carcinoma, Ductal, Breast radiotherapy
Carcinoma, Lobular pathology
Carcinoma, Lobular radiotherapy
Computational Biology
Female
Humans
Middle Aged
Prognosis
Radiotherapy, Adjuvant
Biomarkers, Tumor genetics
Breast Neoplasms genetics
Carcinoma, Ductal, Breast genetics
Carcinoma, Lobular genetics
Gene Expression Regulation, Neoplastic radiation effects
Radiation Tolerance genetics
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1791-2431
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 30015959
- Full Text :
- https://doi.org/10.3892/or.2018.6567