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Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis .
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2018 Jul 13; Vol. 23 (7). Date of Electronic Publication: 2018 Jul 13. - Publication Year :
- 2018
-
Abstract
- Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus , an endophytic fungus isolated from Cordyceps sinensis . Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC <subscript>50</subscript> values of 23.95 µM and 32.70 µM, respectively.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 30011828
- Full Text :
- https://doi.org/10.3390/molecules23071709