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Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2018 Oct; Vol. 81, pp. 108-114. Date of Electronic Publication: 2018 Jul 29. - Publication Year :
- 2018
-
Abstract
- Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the α7 nicotinic receptor (nAChR) and catalase activity in hippocampus. Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an α7 nAChR deficit in the hippocampus, induced by oxidative stress.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Female
Male
Pregnancy
Animals, Newborn
Catalase metabolism
Lactation
Rats, Wistar
RNA, Messenger metabolism
alpha7 Nicotinic Acetylcholine Receptor genetics
Fluorides toxicity
Hippocampus drug effects
Hippocampus metabolism
Memory drug effects
Oxidative Stress drug effects
Prenatal Exposure Delayed Effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1708
- Volume :
- 81
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 30009953
- Full Text :
- https://doi.org/10.1016/j.reprotox.2018.07.078