Eukaryotic DNA polymerases.

Authors :: Jain R
Aggarwal AK
Rechkoblit O
Source :: Current opinion in structural biology [Curr Opin Struct Biol] 2018 Dec; Vol. 53, pp. 77-87. Date of Electronic Publication: 2018 Jul 10.
Publication Year :: 2018
Abstract: The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for cancer therapy.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)