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Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation.
- Source :
-
Organic letters [Org Lett] 2018 Aug 03; Vol. 20 (15), pp. 4654-4658. Date of Electronic Publication: 2018 Jul 13. - Publication Year :
- 2018
-
Abstract
- For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on α-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 20
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 30004710
- Full Text :
- https://doi.org/10.1021/acs.orglett.8b01961