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The structural gene for aldolase B (ALDB) maps to 9q13----32.

Authors :
Henry I
Gallano P
Besmond C
Weil D
Mattei MG
Turleau C
Boué J
Kahn A
Junien C
Source :
Annals of human genetics [Ann Hum Genet] 1985 Jul; Vol. 49 (3), pp. 173-80.
Publication Year :
1985

Abstract

We used a cloned cDNA probe for the B subunit of human aldolase (ALDB) and Southern blotting techniques to analyse DNA from a series of rodent X human somatic cell hybrids for the presence of specific ALDB-related sequences. Our results provide evidence for the assignment of the gene for ALDB to chromosome 9. Moreover, by direct gene dosage determination in two patients with chromosome 9 unbalanced rearrangements and by in situ hybridization we refined the regional chromosomal assignment to 9q13----q32 and most probably to 9q21.3----9q22.2.

Details

Language :
English
ISSN :
0003-4800
Volume :
49
Issue :
3
Database :
MEDLINE
Journal :
Annals of human genetics
Publication Type :
Academic Journal
Accession number :
3000275
Full Text :
https://doi.org/10.1111/j.1469-1809.1985.tb01691.x