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Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia.
- Source :
-
Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2018 Dec 01; Vol. 25 (12), pp. 1188-1195. Date of Electronic Publication: 2018 Jul 12. - Publication Year :
- 2018
-
Abstract
- Aim: We aimed to clarify post-prandial accumulation of remnant-like particles (RLP) in patients with sitosterolemia.<br />Methods: Oral fat tolerance test cream (Jomo Shokuhin, Takasaki, Japan) 50 g was given per body surface area (m <superscript>2</superscript> ); blood sampling was performed at 2 h intervals up to 6 h. Plasma lipoprotein fractions and RLP fractions were determined in four sitosterolemic subjects with double mutations in ATP-binding cassette (ABC) sub-family G member 5 or member 8 (ABCG5 or ABCG8) gene (mean age=18 yr, median low-density lipoprotein cholesterol [LDL-C]=154 mg/dL), six heterozygous carriers (mean age=31 yr, median LDL-C=105 mg/dL), and five subjects with heterozygous familial hypercholesterolemia (FH, mean age=32 yr, median LDL-C=221 mg/dL). The incremental area under curve (iAUC) of lipids, including LDL-C, apolipoprotein B-48 (apoB48), RLP cholesterol (RLP-C), and RLP triglyceride (RLP-TG) were evaluated.<br />Results: After oral fat load, there was no significant difference of the iAUC of LDL-C between sitosterolemia and heterozygous FH, whereas the iAUC of apoB48 was significantly larger in the sitosterolemic subjects compared with that of heterozygous FH (2.9 µg/mL×h vs. 1.3 µg/mL×h, p<0.05). Under these conditions, the iAUCs of RLP-C and RLP-TG levels were significantly larger in the sitosterolemic subject compared with those of heterozygous FH (9.5 mg/dL×h vs. 5.7 mg/dL×h, p<0.05; 149 mg/dL×h vs. 40 mg/dL×h, p<0.05, respectively), whereas those of heterozygous carriers were comparable with those with heterozygous FH.<br />Conclusions: Post-prandial lipoprotein metabolism in sitosterolemia appeared to be impaired, leading to their elevation in serum sterol levels. (UMIN Clinical Trials Registry number, UMIN000020330).
- Subjects :
- Adolescent
Adult
Female
Follow-Up Studies
Heterozygote
Humans
Hypercholesterolemia epidemiology
Hypercholesterolemia metabolism
Hypercholesterolemia pathology
Incidence
Intestinal Diseases epidemiology
Intestinal Diseases pathology
Japan epidemiology
Lipid Metabolism, Inborn Errors epidemiology
Lipid Metabolism, Inborn Errors pathology
Male
Phytosterols metabolism
Postprandial Period
Prognosis
Biomarkers metabolism
Cholesterol metabolism
Hypercholesterolemia physiopathology
Intestinal Diseases metabolism
Lipid Metabolism, Inborn Errors metabolism
Lipoproteins metabolism
Phytosterols adverse effects
Triglycerides metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1880-3873
- Volume :
- 25
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of atherosclerosis and thrombosis
- Publication Type :
- Academic Journal
- Accession number :
- 29998912
- Full Text :
- https://doi.org/10.5551/jat.44768