Ventral hernia repair in rat using nanofibrous polylactic acid/polypropylene meshes.

Authors :: Xiaolong Y
Xiaoyan H
Bo W
Jianglong H
Xiaofeng Y
Xiao T
Zongheng Z
Linbo L
Zefeng Z
Hongbo W
Source :: Nanomedicine (London, England) [Nanomedicine (Lond)] 2018 Sep; Vol. 13 (17), pp. 2187-2199. Date of Electronic Publication: 2018 Jul 12.
Publication Year :: 2018
Abstract: Aim: In the present study, we combined a nanofibrous polylactic acid (PLA) scaffold fabricated by electrospinning with a polypropylene (PP) material to generate a new type of mesh for hernia repair.<br />Materials & Methods: The PLA/PP mesh was tested with tensile testing, in vitro cytocompatibility and degradation. A total of 90 rats were randomly allocated to PLA/PP, PP and polyester (PE) mesh groups for the in vivo study to evaluate the properties of PLA/PP mesh.<br />Results: PLA/PP mesh had superior mechanical properties. It also resulted in less inflammation adhesion formation (p < 0.05), which was related to the TGF-β1/Smad pathway. The distribution of collagen I and III in PLA/PP mesh was also superior to those in the other two groups (p < 0.05).<br />Conclusion: The PLA/PP mesh would be suitable for ventral hernia repair in the future.

Subjects :: Animals
Biocompatible Materials
Cell Line
Collagen Type I metabolism
Collagen Type III metabolism
Humans
Inflammation prevention & control
Male
Nanofibers therapeutic use
Rats, Sprague-Dawley
Tissue Adhesions prevention & control
Tissue Engineering
Hernia, Ventral therapy
Nanofibers chemistry
Polyesters chemistry
Polypropylenes chemistry
Surgical Mesh

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