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Nondestructive Assessment of Articular Cartilage Electromechanical Properties after Osteochondral Autologous and Allogeneic Transplantation in a Goat Model.
- Source :
-
Cartilage [Cartilage] 2020 Jul; Vol. 11 (3), pp. 348-357. Date of Electronic Publication: 2018 Jul 12. - Publication Year :
- 2020
-
Abstract
- Objective: To determine the applicability of a minimally invasive diagnostic device to evaluate the quality of articular cartilage following autologous (OAT) and allogeneic (OCA) osteochondral graft transplantation in goat model.<br />Design: OAT grafts were harvested from lateral femoral condyles (LFCs) and transplanted into osteochondral defects created in medial femoral condyles (MFCs) of contralateral knees. OCA grafts were transplanted into MFC condyles after in vitro storage. Autologous platelet-rich plasma (PRP) was administered intraarticularly after the surgery and at 1 and 2 months postoperatively. OAT and OCA grafts were evaluated macroscopically (Oswestry arthroscopy score [OAS]), electromechanically (quantitative parameter, QP), and histologically (O'Driscoll score, safranin O staining intensity) at 3 and 6 months after transplantation. Results were compared with preoperative graft evaluation.<br />Results: Transplanted cartilage deteriorated within 6 months in all groups. Cartilage quality was better retained in OAT group compared with a decline in OCA group. QP and OAS scores were comparable in OAT and OCA groups at 3 months, but superior in OAT group at 6 months, according to all the methods applied. PRP injections significantly improved QP and OAS score at 6 months compared with 3 months in OAT group. QP moderately correlated with OAS, O'Driscoll score, and safranin O staining intensity.<br />Conclusions: Grafts did not retain preoperative quality parameters at 6 months follow-up; however, OAT were superior to OCA grafts. PRP may have a beneficial effect on macroscopic and electromechanical properties of cartilage; however, histological improvement is yet to be proved. Electromechanical diagnostic device enables reliable assessment of transplanted cartilage.
- Subjects :
- Animals
Arthroscopy instrumentation
Bone Transplantation methods
Disease Models, Animal
Femoral Fractures surgery
Femur
Goats
Intra-Articular Fractures surgery
Knee Joint surgery
Mechanical Phenomena
Platelet-Rich Plasma
Transplantation, Autologous
Transplantation, Homologous
Allografts physiopathology
Arthroscopy methods
Autografts physiopathology
Cartilage, Articular physiopathology
Mechanical Tests methods
Subjects
Details
- Language :
- English
- ISSN :
- 1947-6043
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cartilage
- Publication Type :
- Academic Journal
- Accession number :
- 29998744
- Full Text :
- https://doi.org/10.1177/1947603518786543