Extracellular Vesicles as a Platform for Glioma Therapeutic Development.

Authors :: Santiago-Dieppa DR
Gonda DD
Cheung VJ
Steinberg JA
Carter BS
Chen CC
Source :: Progress in neurological surgery [Prog Neurol Surg] 2018; Vol. 32, pp. 172-179. Date of Electronic Publication: 2018 Jul 10.
Publication Year :: 2018
Abstract: Normal and pathologic cells secrete extracellular vesicles (EV), which are defined as 30-2,000 nm spherical organelles. It has been found that EV mediate various biological functions including cellular remodeling and export of biomolecules, extracellular communication, immune stimulation and suppression, and modulation of the cellular microenvironment. EV secreted by human glioma cells contain a wealth of tumor-specific proteins and nucleic acids that can be isolated from patients with these neoplasms. Thus, EV contribute to the development of biomarkers, and additionally have certain therapeutic potential for possible use in neuro-oncology and neurosurgery.<br /> (© 2018 S. Karger AG, Basel.)