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Can diffusion weighting replace gadolinium enhancement in magnetic resonance enterography for inflammatory bowel disease in children?
- Source :
-
Pediatric radiology [Pediatr Radiol] 2018 Sep; Vol. 48 (10), pp. 1432-1440. Date of Electronic Publication: 2018 Jul 07. - Publication Year :
- 2018
-
Abstract
- Background: Contrast-enhanced MRI is often used for diagnosis and follow-up of children with inflammatory bowel disease.<br />Objective: To compare the accuracy of diffusion-weighted MRI (DWI) to contrast-enhanced MRI in children with known or suspected inflammatory bowel disease.<br />Materials and Methods: This retrospective, consecutive study included 55 children. We used ileo-colonoscopy and histology as the reference standard from the terminal ileum to the rectum, and contrast-enhanced MRI as the reference standard proximal to the terminal ileum. DWI and contrast-enhanced MRI sequences were independently reviewed and compared per patient and per segment to these reference standards and to the follow-up for each child.<br />Results: We obtained endoscopic data for 340/385 colonic and ileal segments (88%). The rate of agreement per segment between DWI and endoscopy was 64%, and the rate of agreement between contrast-enhanced MRI and endoscopy was 59%. Per patient, sensitivity and specificity of bowel wall abnormalities as compared to the endoscopy were 87% and 100% for DWI, and 70% and 100% for contrast-enhanced MRI, respectively. Positive and negative predictive values were, respectively, 100% and 57% for DWI, and 96% and 41% for contrast-enhanced MRI. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of DWI compare to contrast-enhanced MRI in the segments proximal to the terminal ileum were 90%, 98%, 90%, 98% and 96%, respectively.<br />Conclusion: The diagnostic performance of DWI is competitive to that of contrast-enhanced MRI in children with known or suspected inflammatory bowel disease.
- Subjects :
- Adolescent
Child
Child, Preschool
Colonoscopy
Female
Humans
Male
Predictive Value of Tests
Sensitivity and Specificity
Contrast Media administration & dosage
Diffusion Magnetic Resonance Imaging
Gadolinium administration & dosage
Image Enhancement methods
Inflammatory Bowel Diseases diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1998
- Volume :
- 48
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Pediatric radiology
- Publication Type :
- Academic Journal
- Accession number :
- 29982955
- Full Text :
- https://doi.org/10.1007/s00247-018-4169-x