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Urinary peptidomic biomarkers of renal function in heart transplant recipients.
- Source :
-
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2019 Aug 01; Vol. 34 (8), pp. 1336-1343. - Publication Year :
- 2019
-
Abstract
- Background: Chronic kidney disease (CKD) is common in patients after heart transplantation (HTx). We assessed whether in HTx recipients the proteomic urinary classifier CKD273 or sequenced urinary peptides revealing the parental proteins correlated with the estimated glomerular filtration rate (eGFR).<br />Methods: In 368 HTx patients, we measured the urinary peptidome and analysed CKD273 and 48 urinary peptides with a detectable signal in >95% of participants. After 9.1 months (median), eGFR and the urinary biomarkers were reassessed.<br />Results: In multivariable Bonferroni-corrected analyses of the baseline data, a 1-SD increase in CKD273 was associated with a 11.4 [95% confidence interval (CI) 7.25-15.5] mL/min/1.73 m2 lower eGFR and an odds ratio of 2.63 (1.56-4.46) for having eGFR <60 mL/min/1.73 m2. While relating eGFR category at follow-up to baseline urinary biomarkers, CKD273 had higher (P = 0.007) area under the curve (0.75; 95% CI 0.70-0.80) than 24-h proteinuria (0.64; 95% CI 0.58-0.69), but additional adjustment for baseline eGFR removed significance of both biomarkers. In partial least squares analysis, the strongest correlates of the multivariable-adjusted baseline eGFR were fragments of collagen I (positive) and the mucin-1 subunit α (inverse). Associations between the changes in eGFR and the urinary markers were inverse for CKD273 and mucin-1 and positive for urinary collagen I.<br />Conclusions: With the exception of baseline eGFR, CKD273 was more closer associated with imminent renal dysfunction than 24-h proteinuria. Fragments of collagen I and mucin-1-respectively, positively and inversely associated with eGFR and change in eGFR-are single-peptide markers associated with renal dysfunction.<br /> (© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA.)
- Subjects :
- Adult
Aged
Biomarkers urine
Collagen Type I urine
Female
Glomerular Filtration Rate
Heart Diseases urine
Humans
Kidney Function Tests
Least-Squares Analysis
Male
Middle Aged
Mucin-1 urine
Multivariate Analysis
Proteomics
Renal Insufficiency, Chronic etiology
Renal Insufficiency, Chronic urine
Sensitivity and Specificity
Heart Diseases complications
Heart Diseases surgery
Heart Transplantation adverse effects
Peptides urine
Renal Insufficiency, Chronic complications
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2385
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Publication Type :
- Academic Journal
- Accession number :
- 29982668
- Full Text :
- https://doi.org/10.1093/ndt/gfy185