Do GST polymorphisms influence in the pathogenesis of diabetic nephropathy?

Authors :: de Lima RM
Dos Anjos LRB
Alves TB
Coelho ASG
Pedrino GR
da Silva Santos R
da Silva Cruz AH
da Silva Reis AA
Source :: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2018 Dec 15; Vol. 478, pp. 10-16. Date of Electronic Publication: 2018 Jul 05.
Publication Year :: 2018
Abstract: Diabetic patients often develop Diabetic Nephropathy (DN) despite severe long-lasting hyperglycemia, while others develop DN even under intensive insulin therapy. This indicates that factors other than chronic hyperglycemia may also contribute to the susceptibility to the development of DN. The purpose of this case-control study was to investigate the possible role of GSTM1 and GSTT1 deletion polymorphisms, and Single Nucleotide Polymorphism (SNP), GSTP1 313 A > G (Ile105Val), in DN susceptibility. Multiple logistic regression analysis revealed that the occurrence of GST polymorphisms in the Central Brazilian population was not associated with increased risk of DN. However, the presence GSTT1 null genotype suggest an increase trend in systolic blood pressure and opposite inference was observed for the GSTP1 genotype (Ile⁄Val or Val⁄Val). On the order hand, other studies may clarify the relationship of these polymorphisms with DN and help in the prevention of this disease.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)