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Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge.
- Source :
-
NPJ vaccines [NPJ Vaccines] 2018 Jul 03; Vol. 3, pp. 25. Date of Electronic Publication: 2018 Jul 03 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) stem-based antigen, the so-called "mini-HA", has been shown to induce a cross-protective immune response in influenza-naive mice and non-human primates (NHP). However, prior exposure to influenza can have a profound effect on the immune response to subsequent influenza infection and the protective efficacy of vaccination. Here we show that mini-HA, compared to a trivalent influenza vaccine (TIV), elicits a broadened influenza-specific humoral immune response in NHP previously exposed to influenza. Serum transfer experiments showed that antibodies induced by both mini-HA and seasonal vaccine protected mice against lethal challenge with a H1N1 influenza strain heterologous to the H1 HA included in the TIV. However, antibodies elicited by mini-HA showed an additional benefit of protecting mice against lethal heterosubtypic H5N1 influenza challenge, associated with H5 HA-specific functional antibodies.<br />Competing Interests: All authors are, or have been, employees of Janssen Vaccines & Prevention B.V., Pharmaceutical companies of Johnson and Johnson or the Biomedical Primate Research Centre (BPRC), Department of Virology, Division of Cell Mediated Immunity.
Details
- Language :
- English
- ISSN :
- 2059-0105
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- NPJ vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 29977611
- Full Text :
- https://doi.org/10.1038/s41541-018-0063-7