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A critically ill patient after a colchicine overdose below the lethal dose: a case report.
A critically ill patient after a colchicine overdose below the lethal dose: a case report.
- Source :
-
Journal of medical case reports [J Med Case Rep] 2018 Jul 04; Vol. 12 (1), pp. 191. Date of Electronic Publication: 2018 Jul 04. - Publication Year :
- 2018
-
Abstract
- Background: Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported.<br />Case Presentation: An 18-year-old Japanese woman who had taken an overdose of prescription colchicine (15 mg; 0.2 mg/kg) was brought to our emergency out-patient department. Although her colchicine intake was below 0.8 mg/kg (considered the lethal dose), she reached a critical state and underwent three phases characterizing colchicine poisoning (gastrointestinal symptoms, multiple organ failure, and recovery). Her condition was critical, with a Sequential Organ Failure Assessment score of a maximum of 14.<br />Conclusions: Patients might reach a critical stage after colchicine ingestion at a non-lethal dose. Thus, it might be necessary to review which dose of colchicine should be considered lethal.
Details
- Language :
- English
- ISSN :
- 1752-1947
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medical case reports
- Publication Type :
- Academic Journal
- Accession number :
- 29970148
- Full Text :
- https://doi.org/10.1186/s13256-018-1737-5