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Treatment of Syphilis-Associated Cerebral Vasculitis: Reappearance of an Old Question.
- Source :
-
The American journal of medicine [Am J Med] 2018 Dec; Vol. 131 (12), pp. 1516-1519. Date of Electronic Publication: 2018 Jul 02. - Publication Year :
- 2018
-
Abstract
- Background: Cerebral vasculitis caused by neurosyphilis is a re-emerging problem with diagnostic and treatment issues, especially for human immunodeficiency virus patients.<br />Methods: We present a case of relapsing syphilis-associated cerebral vasculitis, despite the recommended first-line antibiotic treatment, that was successfully treated with a second intravenous penicillin G course and corticosteroids.<br />Results: A 50-year old man went to the emergency department for bilateral episodes of red and painful eyes with progressive but severe visual acuity loss. He was diagnosed with bilateral panuveitis and neurosyphilis favored by an unknown human immunodeficiency virus infection with a CD4 count of 236 mm <superscript>3</superscript> . Despite appropriate and well-conducted treatment including intravenous penicillin G, short-term corticosteroid, and highly active antiretroviral therapy, a symptomatic relapse of the syphilis-associated cerebral vasculitis occurred. After a second course of penicillin and corticosteroids, he made a complete recovery.<br />Conclusions: Neurosyphilis and human immunodeficiency virus co-infection is a reappearing challenging situation that should be considered with care by physicians because recommended antibiotic treatment sometimes fails. Corticosteroid therapy should be discussed in case of cerebral vasculitis.<br /> (Copyright © 2018. Published by Elsevier Inc.)
- Subjects :
- Adrenal Cortex Hormones administration & dosage
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents therapeutic use
Antiretroviral Therapy, Highly Active
Aspirin administration & dosage
Aspirin therapeutic use
HIV Infections complications
Humans
Male
Middle Aged
Panuveitis etiology
Penicillin G administration & dosage
Adrenal Cortex Hormones therapeutic use
Neurosyphilis complications
Penicillin G therapeutic use
Vasculitis, Central Nervous System drug therapy
Vasculitis, Central Nervous System etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1555-7162
- Volume :
- 131
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 29969615
- Full Text :
- https://doi.org/10.1016/j.amjmed.2018.06.005