Sarcoidosis in Patients with Antisynthetase Syndrome: Presentation and Outcome.

Authors :: Couture P
Brillet PY
Varin S
Le Goff B
Meyer A
Sibilia J
Jouneau S
Valeyre D
Hervier B
Uzunhan Y
Source :: The Journal of rheumatology [J Rheumatol] 2018 Aug; Vol. 45 (9), pp. 1296-1300. Date of Electronic Publication: 2018 Jul 01.
Publication Year :: 2018
Abstract: Objective: To investigate the uncommon co-occurrence of antisynthetase syndrome (AS) and sarcoidosis.<br />Methods: From 2000 to 2015, patients with sarcoidosis were extracted from a retrospective multicentric cohort of 352 patients with AS.<br />Results: Ten patients (2.8%; 6 men, 8 whites, 5 smokers, median age 50 yrs) had both AS and sarcoidosis. Most of the time, sarcoidosis and AS occurred simultaneously (n = 7). Antibody testing revealed anti-Jo1 (n = 5), anti-PL12 (n = 4), or anti-PL7 (n = 1). Finally, no patient had a worsening of muscular condition, 5 patients presented respiratory deterioration, 3 remained stable, and 2 showed improvement.<br />Conclusion: Sarcoidosis may be underdiagnosed in patients with AS.