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Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders.
- Source :
-
Fertility and sterility [Fertil Steril] 2018 Aug; Vol. 110 (3), pp. 496-505.e1. Date of Electronic Publication: 2018 Jun 28. - Publication Year :
- 2018
-
Abstract
- Objective: To evaluate effects of autologous stem cell ovarian transplant (ASCOT) on ovarian reserve and IVF outcomes of women who are poor responders with very poor prognosis.<br />Design: Prospective observational pilot study.<br />Setting: University hospital.<br />Patient(s): Seventeen women who are poor responders.<br />Intervention(s): Ovarian infusion of bone marrow-derived stem cells.<br />Main Outcome Measure(s): Serum antimüllerian hormone levels and antral follicular count (AFC), punctured follicles, and oocytes retrieved after stimulation (controlled ovarian stimulation) were measred. Apheresis was analyzed for growth factor concentrations.<br />Result(s): The ASCOT resulted in a significant improvement in AFC 2 weeks after treatment. With an increase in AFC of three or more follicles and/or two consecutive increases in antimüllerian hormone levels as success criteria, ovarian function improved in 81.3% of women. These positive effects were associated with the presence of fibroblast growth factor-2 and thrombospondin. During controlled ovarian stimulation, ASCOT increased the number of stimulable antral follicles and oocytes, but the embryo euploidy rate was low (16.1%). Five pregnancies were achieved: two after ET, three by natural conception.<br />Conclusion(s): Our results suggest that ASCOT optimized the mobilization and growth of existing follicles, possibly related to fibroblast growth factor-2 and thrombospondin-1 within apheresis. The ASCOT improved follicle and oocyte quantity enabling pregnancy in women who are poor responders previously limited to oocyte donation.<br />Clinical Trial Registration Number: NCT02240342.<br /> (Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Female
Fertilization in Vitro methods
Fertilization in Vitro trends
Humans
Infertility, Female diagnostic imaging
Ovary cytology
Pilot Projects
Prospective Studies
Stem Cell Transplantation trends
Transplantation, Autologous
Treatment Outcome
Infertility, Female therapy
Ovarian Reserve physiology
Ovary physiology
Ovary transplantation
Reproduction physiology
Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 110
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 29960701
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2018.04.025