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Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2018 Oct; Vol. 80, pp. 216-222. Date of Electronic Publication: 2018 Jun 27. - Publication Year :
- 2018
-
Abstract
- Lambertellin (1) and ergosta-5,7,22-trien-3-ol (2) were isolated from the solid rice fermentation of the plant pathogenic fungus Pycnoporus sanguineus MUCL 51321. Their structures were elucidated using comprehensive spectroscopic methods. The isolated compounds were tested on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Lambertellin (1) exhibited promising inhibitory activity against nitric oxide (NO) production with IC <subscript>50</subscript> value of 3.19 µM, and it significantly inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). Lambertellin (1) also decreased the expression of pro-inflammatory cytokines IL-6 and IL-1β. The study of the mechanistic pathways revealed that lambertellin (1) exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 macrophage cells by modulating the activation of the mitogen activated protein kinase (MAPK) and nuclear factor κB (NF-κB) signaling pathways. Therefore, lambertellin (1) could be a promising lead compound for the development of new anti-inflammatory drugs.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Cyclooxygenase 2 genetics
Cyclooxygenase 2 metabolism
Down-Regulation drug effects
Lipopolysaccharides pharmacology
Macrophages cytology
Macrophages drug effects
Macrophages metabolism
Mice
Naphthalenes isolation & purification
Naphthalenes pharmacology
Nitric Oxide metabolism
Nitric Oxide Synthase Type II genetics
Nitric Oxide Synthase Type II metabolism
Pycnoporus metabolism
RAW 264.7 Cells
Signal Transduction drug effects
Spiro Compounds isolation & purification
Spiro Compounds pharmacology
Anti-Inflammatory Agents chemistry
Mitogen-Activated Protein Kinases metabolism
NF-kappa B metabolism
Naphthalenes chemistry
Pycnoporus chemistry
Spiro Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29957490
- Full Text :
- https://doi.org/10.1016/j.bioorg.2018.06.021