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RETRACTED: Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Oct; Vol. 106, pp. 117-124. Date of Electronic Publication: 2018 Jun 26. - Publication Year :
- 2018
-
Abstract
- This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. An Expression of Concern for this article was previously published while an investigation was conducted (see related editorial: https://doi.org/10.1016/j.biopha.2022.113812). This retraction notice supersedes the Expression of Concern published earlier. Concerns were raised about the provenance of the flow cytometry data shown in Figure 5A, as detailed here: https://pubpeer.com/publications/46C8B5439C5C617A60494BA4C15479; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. Independent analysis also identified additional suspected image duplications between the Bax and Bcl-2 Western blots in Figure 6A. The journal requested the corresponding author comment on these concerns and provide the associated raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.<br /> (Copyright © 2018. Published by Elsevier Masson SAS.)
- Subjects :
- Animals
Cell Hypoxia
Cell Survival drug effects
Cells, Cultured
Cellular Microenvironment
Cytoprotection
Dose-Response Relationship, Drug
Endothelial Cells enzymology
Endothelial Cells pathology
G1 Phase Cell Cycle Checkpoints drug effects
Janus Kinase 2 antagonists & inhibitors
Janus Kinase 2 genetics
Microvessels enzymology
Microvessels pathology
Myocardial Reperfusion Injury enzymology
Myocardial Reperfusion Injury genetics
Myocardial Reperfusion Injury pathology
Protein Kinase Inhibitors pharmacology
Proto-Oncogene Proteins c-bcl-2 genetics
Proto-Oncogene Proteins c-bcl-2 metabolism
Rats, Sprague-Dawley
S Phase Cell Cycle Checkpoints drug effects
STAT3 Transcription Factor antagonists & inhibitors
STAT3 Transcription Factor genetics
Tyrphostins pharmacology
bcl-2-Associated X Protein genetics
bcl-2-Associated X Protein metabolism
Matrines
Alkaloids pharmacology
Apoptosis drug effects
Endothelial Cells drug effects
Janus Kinase 2 metabolism
Microvessels drug effects
Myocardial Reperfusion Injury prevention & control
Quinolizines pharmacology
STAT3 Transcription Factor metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 106
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 29957461
- Full Text :
- https://doi.org/10.1016/j.biopha.2018.06.003