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Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.

Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.

Authors :
Kurz ARM
Catz SD
Sperandio M
Source :
Trends in immunology [Trends Immunol] 2018 Aug; Vol. 39 (8), pp. 656-669. Date of Electronic Publication: 2018 Jun 26.
Publication Year :
2018

Abstract

The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1471-4981
Volume :
39
Issue :
8
Database :
MEDLINE
Journal :
Trends in immunology
Publication Type :
Academic Journal
Accession number :
29954663
Full Text :
https://doi.org/10.1016/j.it.2018.05.003