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Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.
Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.
- Source :
-
Trends in immunology [Trends Immunol] 2018 Aug; Vol. 39 (8), pp. 656-669. Date of Electronic Publication: 2018 Jun 26. - Publication Year :
- 2018
-
Abstract
- The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency syndrome with features of autoimmune disease. In line with this, Mst1-deficient mice exhibit severe defects in lymphocyte and neutrophil functions as well as disturbed intracellular vesicle transport. These findings spurred research on the noncanonical functions of MST1 in leukocytes. Here, we summarise the latest findings on this topic and discuss MST1 as a critical regulator of various leukocyte functions.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Biological Evolution
Hippo Signaling Pathway
Humans
MAP Kinase Kinase Kinases metabolism
Mice
Signal Transduction
Autoimmune Diseases genetics
Leukocytes metabolism
MAP Kinase Kinase Kinases genetics
Protein Serine-Threonine Kinases metabolism
Severe Combined Immunodeficiency genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1471-4981
- Volume :
- 39
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29954663
- Full Text :
- https://doi.org/10.1016/j.it.2018.05.003