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Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy.
- Source :
-
Cancer communications (London, England) [Cancer Commun (Lond)] 2018 Jun 26; Vol. 38 (1), pp. 39. Date of Electronic Publication: 2018 Jun 26. - Publication Year :
- 2018
-
Abstract
- Background: Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving therapy.<br />Methods: Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were reviewed. The Kaplan-Meier method was used to estimate locoregional recurrence, breast cancer-free survival, and breast cancer-specific survival rates. These rates were then compared using log-rank tests. Outcomes and age were modeled by Cox proportional hazards. Fractional polynomials were then used to test for non-linear relationships between age and outcomes.<br />Results: Patients ≤ 40 years old were more likely to have locoregional recurrence than were older patients (Hazard ratio [HR] = 2.32, P < 0.001). Locoregional recurrence rates decreased year-on-year by 4% for patients with luminal-type breast cancers, compared with 8% for those with triple-negative cancers. Similarly, breast cancer-free survival rates increased year-on-year by 4% versus 8% for luminal-type and triple-negative cancers, respectively. Breast cancer-specific survival rates increased with age by 5% year-on-year. Both breast cancer-free survival and breast cancer-specific survival rates in patients with luminal cancers exhibited a non-linear ("L-shaped") relationship-where decreasing age at presentation was associated with escalating risks of relapse and death. The influence of age on overall survival was confounded by competing non-cancer deaths in older women, resulting in a "U-shaped" relationship.<br />Conclusions: Young Asian breast cancer patients have a continuous year-on-year increase in rates of disease relapse and cancer deaths compared with older patients with no apparent threshold.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Asian People statistics & numerical data
Breast Neoplasms ethnology
Breast Neoplasms radiotherapy
Combined Modality Therapy
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Neoplasm Recurrence, Local
Outcome Assessment, Health Care statistics & numerical data
Proportional Hazards Models
Retrospective Studies
Singapore
Triple Negative Breast Neoplasms ethnology
Triple Negative Breast Neoplasms radiotherapy
Young Adult
Breast Neoplasms surgery
Mastectomy, Segmental methods
Outcome Assessment, Health Care methods
Triple Negative Breast Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2523-3548
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer communications (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29941044
- Full Text :
- https://doi.org/10.1186/s40880-018-0310-3