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Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates.
- Source :
-
Journal of food science [J Food Sci] 2018 Jul; Vol. 83 (7), pp. 1781-1791. Date of Electronic Publication: 2018 Jun 21. - Publication Year :
- 2018
-
Abstract
- Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL-2 and COX-2 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies.<br /> (© 2018 Institute of Food Technologists®.)
- Subjects :
- Animals
Cell Movement drug effects
Cell Proliferation drug effects
Coronary Disease drug therapy
DNA Damage drug effects
Humans
Iridoid Glucosides
Iridoids pharmacology
Neoplasm Invasiveness prevention & control
Neoplasms drug therapy
Neoplasms prevention & control
Neovascularization, Pathologic prevention & control
Olea
Phenylethyl Alcohol pharmacology
Phenylethyl Alcohol therapeutic use
Pyrans
Antineoplastic Agents
Iridoids therapeutic use
Olive Oil chemistry
Phenylethyl Alcohol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1750-3841
- Volume :
- 83
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of food science
- Publication Type :
- Academic Journal
- Accession number :
- 29928786
- Full Text :
- https://doi.org/10.1111/1750-3841.14198