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[Similarity of Clinically Significant Neuropsychiatric Adverse Reactions Listed in Package Inserts between the Anti-influenza Drugs Oseltamivir and Amantadine (Possibility Attributable to Common Pharmacological Effects)].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2018 Sep 01; Vol. 138 (9), pp. 1201-1215. Date of Electronic Publication: 2018 Jun 20. - Publication Year :
- 2018
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Abstract
- The anti-influenza virus drug oseltamivir has been reported to have several pharmacological actions including blocking of nicotinic acetylcholine receptor channels and activation of the dopaminergic system. These pharmacological actions highly overlap those of amantadine, another anti-influenza virus drug authorized in Japan, and ester-type local anesthetics. Moreover, oseltamivir and amantadine can clinically induce similar adverse neuropsychiatric reactions. In the present study, from the database of the Pharmaceuticals and Medical Devices Agency (PMDA), we surveyed 2576 drugs for which neuropsychiatric side effects similar to those of oseltamivir, amantadine and local anesthetics (abnormal behavior, confusion, consciousness disturbance, convulsion, delirium, delusion, hallucination, myoclonus, tremor) are listed as "clinically significant adverse reactions", and found 327 that had at least one of these adverse reactions. Other neuraminidase inhibitors (laninamivir, peramivir and zanamivir) did not elicit such adverse reactions. By discussing the pharmacological effects of drugs that elicit these adverse reactions, we propose that the similarity of adverse neuropsychiatric reactions between oseltamivir and amantadine is possibly attributable to their common pharmacological effects.
- Subjects :
- Amantadine chemistry
Amantadine pharmacology
Antiviral Agents chemistry
Antiviral Agents pharmacology
Dopamine Agonists
Enzyme Inhibitors pharmacology
Humans
Influenza, Human drug therapy
Molecular Conformation
Neuraminidase antagonists & inhibitors
Nicotinic Antagonists
Oseltamivir chemistry
Oseltamivir pharmacology
Amantadine adverse effects
Antiviral Agents adverse effects
Drug Labeling
Enzyme Inhibitors administration & dosage
Mental Disorders chemically induced
Nervous System Diseases chemically induced
Oseltamivir adverse effects
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1347-5231
- Volume :
- 138
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 29925727
- Full Text :
- https://doi.org/10.1248/yakushi.18-00022