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Relevance of anti-T monoclonal antibodies in the study of children with primary immunodeficiencies.
- Source :
-
Bollettino dell'Istituto sieroterapico milanese [Boll Ist Sieroter Milan] 1985; Vol. 64 (2), pp. 135-41. - Publication Year :
- 1985
-
Abstract
- T-cell phenotypic analysis with anti-T monoclonal antibodies (MoAb) was performed on 37 children with immunologic disorders. Abnormalities of T-cell differentiation and/or of T-cell subset distribution were observed in many patients. In particular two infants with severe combined immunodeficiency showed immunologically incompetent common thymocytes (OKT6+) in the circulation, in one case a proportion of OKT6+ cells was OKT4-, OKT8-. A boy with a selective T-cell defect synthetized normal levels of Ig classes, despite the marked reduction of helper/inducer T-cells (OKT4+). Irregularities of T-cell subsets were also noted in children with Wiskott-Aldrich syndrome and in some patients with selective IgA defect or hypogammaglobulinaemia. In one of these, in whom the agammaglobulinaemia was caused by EBV infection, a persistently reversed OKT4+/OKT8+ ratio together with an excessive suppressor T-cell function were found more than 10 years after the onset of the disease. Such a case supports the hypothesis that a viral infection may cause, in a predisposed host, both the agammaglobulinaemia and an abnormality of the regulatory T-cell subpopulations. Such abnormalities, together with those found in the other children studied, underline the importance of MoAb against different T-cell antigens for a better characterization of primary immunodeficiencies.
- Subjects :
- Adolescent
Agammaglobulinemia immunology
Child
Child, Preschool
Dysgammaglobulinemia immunology
Herpesvirus 4, Human
Humans
IgA Deficiency
Infant
Infectious Mononucleosis immunology
Lymphocyte Activation
Wiskott-Aldrich Syndrome immunology
Antibodies, Monoclonal immunology
Immunologic Deficiency Syndromes immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-2547
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bollettino dell'Istituto sieroterapico milanese
- Publication Type :
- Academic Journal
- Accession number :
- 2992541