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Age alone is not a contraindication to kidney donation: Outcomes of donor nephrectomy in the elderly.
- Source :
-
Clinical transplantation [Clin Transplant] 2018 Aug; Vol. 32 (8), pp. e13287. Date of Electronic Publication: 2018 Jun 20. - Publication Year :
- 2018
-
Abstract
- With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1.73 m <superscript>2</superscript> ; P < .001). Intraoperative and postoperative complications were similar, except a higher prevalence of <30 day ileus (3% vs 7%; P = .021) and longer postoperative length of stay (LOS) (4.2 vs 4.6 days; P = .005). On multivariate analysis, <30 day ileus and LOS continued to be significantly greater for >60-years-old After >20 years post-DN, systolic blood pressure was significantly higher among >60-years-old (142 vs 125 mm Hg; P < .001) and HTN was diagnosed earlier (9 vs 14 years). After donation, eGFR was significantly lower for >60-years-old but slope of eGFR and rates of end-stage renal disease (ESRD) were not significantly different >20 years post-DN. Thus, kidney donation among carefully selected >60-years-old poses minimal perioperative risks and no added risk of long-term ESRD.<br /> (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Age Factors
Aged
Blood Pressure
Comorbidity
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Assessment
Risk Factors
Contraindications
Kidney Transplantation methods
Living Donors
Nephrectomy statistics & numerical data
Postoperative Complications
Tissue and Organ Harvesting methods
Subjects
Details
- Language :
- English
- ISSN :
- 1399-0012
- Volume :
- 32
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Clinical transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 29923234
- Full Text :
- https://doi.org/10.1111/ctr.13287