The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption.

Authors :: Abdullah MMH
Eck PK
Couture P
Lamarche B
Jones PJH
Source :: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2018 Oct; Vol. 43 (10), pp. 1090-1093. Date of Electronic Publication: 2018 Jun 19.
Publication Year :: 2018
Abstract: Existing evidence on the influence of genetic architecture on serum cholesterol responsiveness to dietary interventions focuses on individual single nucleotide polymorphisms and single nutrients. We associated the combination of ABCG5 rs6720173-C, CYP7A1 rs3808607-TT, and DHCR7 rs760241-GG genotypes with lower low-density lipoprotein cholesterol concentrations relative to the combination of rs6720173-GG, rs3808607-G, and rs760241-A genotypes (-0.37 ± 0.12 (n = 9) vs. +0.38 ± 0.14 mmol/L (n = 7), p = 0.0016) following a blended dairy (3 servings/day for 4 weeks) intervention.

Language :: English
ISSN :: 1715-5320
Volume :: 43
Issue :: 10
Database :: MEDLINE
Journal :: Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
Publication Type :: Academic Journal
Accession number :: 29920211
Full Text :: https://doi.org/10.1139/apnm-2018-0085

Full Text Access

Tools