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Oral administration of a curcumin-phospholipid formulation (Meriva®) for treatment of chronic diabetic macular edema: a pilot study.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2018 Jun; Vol. 22 (11), pp. 3617-3625. - Publication Year :
- 2018
-
Abstract
- Objective: The purpose of this open-label study was to investigate the effect of a curcumin-phospholipid lecithin formulation (Meriva®) on visual acuity and optical coherence tomography (OCT) retinal thickness in patients with chronic diabetic macular edema.<br />Patients and Methods: Curcumin-phospholipid lecithin formulation (Meriva®, Indena S.p.A, Milan, Italy) was administered as tablets (Norflo®, Eye Pharma, Genoa, Italy) twice a day. Visual acuity and macular edema as measured by OCT before and after curcumin-phospholipid formulation treatment were assessed.<br />Results: The study included 12 eyes from 11 patients who completed at least a 3-month follow-up period. After 3 months of therapy, no eyes showed reduction in visual acuity, 16% showed stabilization, and 84% showed improvement. The improvement was statistically significant (p = 0.0072). After 3 months of therapy, 92% of eyes showed reduction of macula edema, 8% showed stabilization, and 0% showed an increase (p = 0.009).<br />Conclusions: Our results, albeit preliminary, suggest that a curcumin-phospholipid formulation (Meriva®), administered as Norflo® tablets, may be feasible in the improvement of visual acuity and reduction of macular edema in patients with diabetic retinopathy.
- Subjects :
- Administration, Oral
Aged
Curcumin chemistry
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 diagnosis
Drug Compounding
Female
Humans
Macular Edema etiology
Macular Edema pathology
Male
Middle Aged
Pilot Projects
Retina diagnostic imaging
Tomography, Optical Coherence
Visual Acuity
Curcumin therapeutic use
Macular Edema drug therapy
Phospholipids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 22
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29917217
- Full Text :
- https://doi.org/10.26355/eurrev_201806_15189