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In Vitro Susceptibility of Burkholderia cepacia Complex Isolated from Cystic Fibrosis Patients to Ceftazidime-Avibactam and Ceftolozane-Tazobactam.

Authors :
Van Dalem A
Herpol M
Echahidi F
Peeters C
Wybo I
De Wachter E
Vandamme P
Piérard D
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Aug 27; Vol. 62 (9). Date of Electronic Publication: 2018 Aug 27 (Print Publication: 2018).
Publication Year :
2018

Abstract

We tested the in vitro susceptibility of ceftazidime-avibactam and ceftolozane-tazobactam and 13 other antibiotics against 91 Burkholderia cepacia complex (BCC) strains isolated from cystic fibrosis patients since 2012. The highest susceptibility (82%) was found for trimethoprim-sulfamethoxazole. Eighty-one and 63% of all BCC strains were susceptible to ceftazidime-avibactam and ceftolozane-tazobactam, respectively. For temocillin, ceftazidime, piperacillin-tazobactam, and meropenem, at least 50% of the strains were susceptible. B. stabilis seems to be more resistant than other BCC species.<br /> (Copyright © 2018 American Society for Microbiology.)

Details

Language :
English
ISSN :
1098-6596
Volume :
62
Issue :
9
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
29914964
Full Text :
https://doi.org/10.1128/AAC.00590-18